chronic cold-water-induced hypothermia impairs memory retrieval and nepeta menthoides as a traditional “hot” herb reverses the impairment

نویسندگان

mohammad mahdi ahmadian-attar department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences,tehran, iran

abolhassan ahmadiani 1-neuroscience research center, shahid beheshti university of medical sciences, tehran, iran.2-department of pharmacology, faculty of medicine, university of malaya, 50603, kuala lumpur, malaysia

mohammad kamalinejad department of pharmacognosy, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

leila dargahi neuroscience research center, shahid beheshti university of medical sciences, tehran, iran.

چکیده

iranian traditional medicine (itm) describes a kind of dementia with similar signs and symptoms of alzheimer’s disease (ad). it explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. itm strategy for treatment of dementia is to heat the brain up by medical “hot” herbs. nepeta menthoides (nm) is one of these “hot” herbs. to evaluate the veracity of itm concept about dementia and its treatment, we first try to examine if coldness of brain can make memory impairment. if so, can nm reverse memory impairment? rats in cold-water-induced hypothermic (cwh) groups were immersed up to the neck in 3.5°c water, for 5 min during 14 consecutive days. as a control, rats were forced to swim in warm water at the same conditions. to eliminate the impact of forced swimming stress, a group of intact rats was also added. after last swimming in day 14, some groups received drug (100 or 500 mg/kg aqueous extract of nm) or vehicle via i.p. injection. learning and memory were assessed by morris water maze, and tau hyperphosphorylation was measured by western blotting. the results showed that cwh impairs learning and memory and induces tau hyperphosphorylation. 100 mg/kg of nm reversed memory impairment as well as tau hyperphosphorylation. itm theory about the relationship between brain hypothermia and dementia is in accordance with our findings.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta menthoides as a Traditional “Hot” Herb Reverses the Impairment

Iranian Traditional Medicine (ITM) describes a kind of dementia with similar signs and symptoms of Alzheimer’s disease (AD). It explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. ITM strategy for treatment of dementia is to heat the brain up by medical “hot” herbs. Nepeta menthoides (NM) is one of these “hot” herb...

متن کامل

Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta menthoides as a Traditional “Hot” Herb Reverses the Impairment

Iranian Traditional Medicine (ITM) describes a kind of dementia with similar signs and symptoms of Alzheimer’s disease (AD). It explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. ITM strategy for treatment of dementia is to heat the brain up by medical “hot” herbs. Nepeta menthoides (NM) is one of these “hot” herb...

متن کامل

Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta menthoides as a Traditional “Hot” Herb Reverses the Impairment

Iranian Traditional Medicine (ITM) describes a kind of dementia with similar signs and symptoms of Alzheimer's disease (AD). It explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. ITM strategy for treatment of dementia is to heat the brain up by medical "hot" herbs. Nepeta menthoides (NM) is one of these "hot" herb...

متن کامل

Pridopidine Reverses Phencyclidine-Induced Memory Impairment

Pridopidine is in clinical trials for Huntington’s disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington’s disease model mice and, in preliminarily reports, Huntington’s disease patients....

متن کامل

Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test

Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction.  Methods: To this end, the kindled animal were prepared via CA1 ...

متن کامل

The effects of swimming exercise and Nepeta menthoides on depression and anxiety induced by reserpine

Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempted to determine and compare the effects of swimming exercise and Nepeta menthoides on reserpine-induced depression in rats.Materials and Methods: Male rats (n=80) were assigned to 8 g...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۳، شماره Supplement، صفحات ۱۸۵-۱۹۳

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023